ea0044p189 | Obesity and Metabolism | SFEBES2016
Fletcher Rachel
, Oldacre-Bartley Lucy
, Doig Craig
, Brenner Charles
, Lavery Gareth
Nicotinamide adenine dinucleotide (NAD+) levels increase during metabolic stress, which acts as a consumed substrate by, amongst other proteins, the sirtuins, which adapt transcriptional programmes to increase energy availability and regulate insulin sensitivity. Thus, maintaining appropriate skeletal muscle NAD+ availability is critical for regulating systemic energy homeostasis. In order to gain better insight into ageing muscle NAD+ dynamics we used ta...